How to make hydrogels more injectable
Gel-like materials that can be injected into the body hold great potential to heal injured tissues or manufacture entirely new tissues. Many researchers are working to develop these hydrogels for biomedical uses, but so far very few have made it into the clinic.Get more news about factory direct sale medical hydrogel wholesaler,you can vist our website!
To help guide in the development of such materials, which are made from microscale building blocks akin to squishy LEGOs, MIT and Harvard University researchers have created a set of computational models to predict the material’s structure, mechanical properties, and functional performance outcomes. The researchers hope that their new framework could make it easier to design materials that can be injected for different types of applications, which until now has been mainly a trial-and-error process.
“It’s really exciting from a material standpoint and from a clinical application standpoint,” says Ellen Roche, an associate professor of mechanical engineering and a member of the Institute for Medical Engineering and Science at MIT. “More broadly, it’s a nice example of taking lab-based data and synthesizing it into something usable that can give you predictive guidelines that could be applied to things beyond these hydrogels.”
Roche and Jennifer Lewis, the Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard, are the senior authors of the study, which appears today in the journal Matter. Connor Verheyen, a graduate student in the Harvard-MIT Program in Health Sciences and Technology, is the lead author of the paper.
Material modeling
When individual hydrogel blocks are densely compacted together, they form a gel-like material known as a granular matrix. These materials can act as a solid or a liquid, depending on the conditions, which makes them good candidates for applications such as 3D-bioprinting engineered tissues. Once injected or implanted into the body, they could release drugs or help to regenerate injured tissue.
“These materials have a lot of flexibility and customizability, so there’s a lot of excitement about using them for biomedical applications,” Verheyen says.
While working in Lewis’ lab, Verheyen, who is co-advised by Lewis and Roche, began trying to figure out how to get these materials to be reliably injectable. This turned out to be a difficult task that required a lot of trial-and-error experimentation, by changing different features of the gels in hopes of optimizing their structure and mechanical behavior for injectability.
“That spurred the effort to take the empirical data, turn it into something that a machine could read and work with, and then ask it to build a predictive map that we could interrogate to help us understand what was going on and how to go to the next step,” he says.
To create their design framework, the researchers broke the assembly process down into several stages. They modeled each of these stages separately, using data from their own experiments, which were done under a variety of different conditions.
In the first stage, the model analyzed how bioblock properties are affected by the starting material of the blocks and how they are assembled. In the second stage, the bioblocks are packed together to form structures called “granular hydrogels.” Through their modeling, the researchers identified several factors that influence the injectability of the final gel, including the size and stiffness of the bioblocks, the viscosity of the interstitial fluid between the blocks, and the dimensions of the needle and syringe used to inject the gel.
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